Another vote that it should start automatically, or at least, it should be a configuration option. Right now, I do this by putting a shortcut in my Startup folder, but the only problem with that is the client remains full screen and TF3D on my Touch Pro won't launch until I minimize the Live Mesh client (???).
Seems strange to me that software that is supposed to keep your device sync'd has to be manually invoked to work! Why can't it work like the mail client does?