Try checking your hard drive for errors. How to check a hard drive for errors -
http://support.microsoft.com/kb/315265 If defrag will not run after checking your hard drive for errors try running the system file checker -
http://support.microsoft.com/kb/310747 If the issue is not resolved please contact support. How to reach support -
http://social.microsoft.com/Forums/en-US/onecareinstallandactivate/thread/30400b52-7f26-4ba0-bc18-17e305329d90
Jim - MVP Windows Live - Forum Moderator - Live One Care - Live Mesh - Microsoft Security Essentials