Does your laptop travel between home and work? If so, you might consider making the laptop host the notebook and connect to that location from both the home and work machines. This way, whenever the laptop is joined to either network (home/work) the notebook will sync and update changes. When not connected, each notebook is in cache mode and the changes will be combined when connected.
I'm not sure that I'd want to use Live Mesh for this as the potential for conflicts is great. If you modify the same file on 2 machines, they won't merge, and you will need to decide which version to keep. I believe that OneNote 2010 will have the capability of having your Notebook be cloud based so that you aren't limited to a local network connection.
If you do decide to go the route of using Live Mesh, you may want to create a new folder on each PC and copy the current OneNote notebook to that new folder. Then, add this folder to Live Mesh and let it sync between the PCs and Live Desktop. Once you are satisfied that it is working, you can close the original OneNote notebook and use the copy that is in the Mesh. Your old notebook can be your local backup.
-steve
Microsoft MVP Windows Live / Windows Live OneCare, Live Mesh, & MS Security Essentials Forums Moderator
