You're off topic for this forum, which is dedicated to Windows Live OneCare. You may want to try the Microsoft Public newsgroups here: http://www.microsoft.com/communities/newsgroups/list/en-us/default.aspx
However, your USB drive should not need driver files loaded externally, they should come from Windows. Refer to the documentation for your drive on how to create a partition and format it for use with Windows.
For your sound problem, you need to identify the sound card, and follow the manufacturer instructions for updating the drivers for Vista. If the card is supported natively by Vista, you should be able to go to Control Panel/System/Device Manager and select the sound card and click Update Drivers under the properties for the card.
-steve
Microsoft MVP Windows Live / Windows Live OneCare Forum Moderator