I moved your post to the Backup forum.
You'll need to reset your backup plan since you have changed the backup destination by using a different drive. That means that you will doing a new full backup instead of an incremental backup.
See this post for how to do this:
http://social.microsoft.com/Forums/en-US/onecarebackupandrestore/thread/5f18a60d-add4-4ff2-87cf-021db7e81917-steve
Microsoft MVP Windows Live / Windows Live OneCare & Live Mesh Forum Moderator