It doesn't run for me on Windows 10 x64. Upon launch it throws an error and offers to rebuild the data directory and restart. Upon restart, it does the exact same thing. Choosing "Cancel" at the dialog does not terminate the program (as it should;
this is a bug), but instead redisplays the error dialog.
I've tried setting compatibility to Windows 8 for the application, but it still doesn't launch properly.
After using Task Manager to force WWT to quit, Windows popped up a compatibility troubleshooter dialog. I ran the troubleshooter, and whatever it did fixed WWT. It now launches and runs properly. Yay, Windows 10!