Not really. There is no supported way to change how CRM looks. Now that MSCRM update cadence is accelerated you really don't want to do too much unsupported customization.
Unsupported customizations
Modifications to any .aspx, .css, .htm, .js, .xml, .jpg, or .gif files or the addition of files in the wwwroot directories of the Microsoft Dynamics CRM application, Microsoft Dynamics CRM tools, or Microsoft Dynamics CRM files located at Program Files\Microsoft
Dynamics CRM. However, if you have made changes to these files, these files are checked for modifications and will not be overwritten.
Ronald