The only way to do that would be to change the configured ports on one of the two IIS sites. You could potentially use port translation on the ISA server listener so that the internal Web Component and CWA services still work over the default 80/443 ports on their respective IPs, but configure the CWA ISA listener to use a different external port. This would unfortunately require the users to supply the port in the URL, as in
http://im.domain.com:444 for example.
Jeff Schertz, PointBridge | MVP | MCITP: Enterprise Messaging | MCTS: OCS