The first backup, of the first computer, may take quite a long time (possibly many hours if you're backing up the one with 600 GB of data first). This is because each cluster of data on the computer has to be transferred to the server and stored in the backup database. Exact speed is dependent on many factors: your network infrastructure, what else is running on the computer being backed up, drivers and NIC hardware, etc. Subsequent backups of that computer, and backups of other computers, should be significantly faster, however; the backup tool uses a concept similar to Single Instance Storage, except at the cluster level, to store only a single instance of each unique cluster in the database.
I'm not on the WHS team, I just post a lot. :)