You may need to first disable backup and then re-enable it.
Open OneCare
Click Change Settings
backup tab
Click change settings in the lower left
Make sure that the first screen for Centralized Backup has "No Centralized backup" selected
Click your PC on the left.
Uncheck the selection for "Turn on backup for this PC."
Click Next and save the revised plan.
Go back to the backup tab and click Change Settings in the lower left once again.
Select your PC and click.
Click Turn on backup
Select the change location link and select the drive you want to use for backup
Modify the schedule as desired for "When"
Select the file types as desired for "What"
Click next and save the revised plan with the new selection.
-steve