michael1201;
Perhaps you're experiencing some contention on your system between security products. What real-time Anti-Virus and Anti-Spyware applications did you previously or do you currently have installed in addition to OneCare? Did you use those application's own un-install and/or cleanup tools if you tried to remove them before you installed OneCare? Often, security applications are installed at very low system levels, and a simple Add/Remove is not enough to remove them completely. Maybe we can provide the location of such removal tools if needed.
You can also look at this thread for additional suggestions...
http://forums.microsoft.com/WindowsOneCare/ShowPost.aspx?PostID=2898722&SiteID=2