Live Mesh 2001 (Live Essentials 2011) - the replacement for Live Sync formerly Foldershare.
Can you set destination folder? Yes!
Ok, what you need to do is to create the share on the source WITHOUT selecting other machines to sync with. If you select the machines at creation-time (by use of the simple checkmark) the destination will be the hard-coded path to the my documents
folder.
After creating the share on the source, go to the first destination-pc (or remote into it) and start the live mesh program. You can now see the shared folder from the sorce-PC with an offer to share/sync it to this pc. Select that option,
and voila - here you can choose any folder as the destination.
A bit clumsy - but it works.
Thomas