I ran a tune up Sunday and can no longer access my Adobe Photoshop. Why would this happen? What do I do to fix the problem?
I can't imagine how OneCare Tune-up would have caused this, so I'd recommend that you contact support.
How to reach support (FAQ) - http://forums.microsoft.com/WindowsOneCare/ShowPost.aspx?PostID=2421771&SiteID=2
-steve
After a tune-up?