是可以的，注意PDB文件要在远程机器上。
参考这里
https://social.msdn.microsoft.com/Forums/zh-CN/4cb8ab42-7883-4e36-b5a6-1a468868407a/visual-studio-2005-remote-debugging?forum=vsdebug
When we remote debugging, Visual Studio Debugger will look for the pdb files from the remote machine and seek the source code on our local machine. If we did not specify where the debugger could find the pdb file, then, the
symbols could not be loaded. In this case, since we put our symbol files on the directory of the application, hence, the remote debugger monitor running on the remote machine could not find this location for the pdb files. One of the ways to let
it know where to find the symbols is, as I suggested above, we could make a share folder on the local machine and add its path to the environment variable on the remote machine to let the remote debugger know where to
find the symbols.
Please take a look at this video on remote debugging with MSVSMON.exe, I believe it could help you:
http://www.microsoft.com/uk/msdn/screencasts/screencast/313/Visual-Studio-2008-Remote-Debugging-with-MSVSMONEXE.aspx
专注于.NET MIS开发框架，C/S架构，SQL Server + ORM(LLBL Gen Pro) + Infragistics WinForms
