Diabling the Safe Mode is not a good practice. You should make sure that they are not System Admin and so that they cannot login into the system even they are booting the computer into safe mode.
However, if you still want to make this happen, you can view in the following link,
http://www.ozzu.com/mswindows-forum/disable-safe-mode-t45092.htmlBut keep in your mind that, you cannot boot it into safe mode as well if the machine has some serious happen and need recoevery.
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